Amplification and overexpression of E2F3 in human bladder cancer.
Oncogene
; 23(8): 1627-30, 2004 Feb 26.
Article
in En
| MEDLINE
| ID: mdl-14716298
ABSTRACT
We demonstrate that, in human bladder cancer, amplification of the E2F3 gene, located at 6p22, is associated with overexpression of its encoded mRNA transcripts and high levels of expression of E2F3 protein. Immunohistochemical analyses of E2F3 protein levels have established that around one-third (33/101) of primary transitional cell carcinomas of the bladder overexpress nuclear E2F3 protein, with the proportion of tumours containing overexpressed nuclear E2F3 increasing with tumour stage and grade. When considered together with the established role of E2F3 in cell cycle progression, these results suggest that the E2F3 gene represents a candidate bladder cancer oncogene that is activated by DNA amplification and overexpression.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transcription Factors
/
Urinary Bladder Neoplasms
/
DNA, Neoplasm
/
Gene Amplification
Limits:
Humans
Language:
En
Journal:
Oncogene
Journal subject:
BIOLOGIA MOLECULAR
/
NEOPLASIAS
Year:
2004
Type:
Article
Affiliation country:
United kingdom