Quantitation of SU1 1248, an oral multi-target tyrosine kinase inhibitor, and its metabolite in monkey tissues by liquid chromatograph with tandem mass spectrometry following semi-automated liquid-liquid extraction.

Barattè, S; Sarati, S; Frigerio, E; James, C A; Ye, C; Zhang, Q

Barattè, S; Sarati, S; Frigerio, E; James, C A; Ye, C; Zhang, Q.

Affiliation

Barattè S; Global Drug Metabolism, Pharmacia, Viale Pasteur 10, 20014 Nerviano, Italy. simona.baratte@pharmacia.com

J Chromatogr A ; 1024(1-2): 87-94, 2004 Jan 23.

Article in En | MEDLINE | ID: mdl-14753710

Subject(s)

Antineoplastic Agents/analysis; Chromatography, Liquid/methods; Enzyme Inhibitors/analysis; Indoles/analysis; Mass Spectrometry/methods; Protein-Tyrosine Kinases/antagonists & inhibitors; Pyrroles/analysis; Animals; Antineoplastic Agents/metabolism; Antineoplastic Agents/pharmacokinetics; Enzyme Inhibitors/metabolism; Enzyme Inhibitors/pharmacokinetics; Haplorhini; Indoles/metabolism; Indoles/pharmacokinetics; Pyrroles/metabolism; Pyrroles/pharmacokinetics; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Sunitinib; Tissue Distribution

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Mass Spectrometry / Protein-Tyrosine Kinases / Chromatography, Liquid / Enzyme Inhibitors / Indoles / Antineoplastic Agents Type of study: Diagnostic_studies Limits: Animals Language: En Journal: J Chromatogr A Year: 2004 Type: Article Affiliation country: Italy

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