Combined status of MUC1 mucin and surfactant apoprotein A expression can predict the outcome of patients with small-size lung adenocarcinoma.
Histopathology
; 44(2): 147-55, 2004 Feb.
Article
in En
| MEDLINE
| ID: mdl-14764058
ABSTRACT
AIM:
Lung cancer is still a disease of high mortality, despite advanced diagnostic techniques. Here, we aim to report a unique method to predict the recurrence and outcome of patients with pulmonary adenocarcinomas. METHODS ANDRESULTS:
Immunohistochemical expression of MUC1 mucin and surfactant apoprotein A (SP-A) was examined in 185 cases of surgically removed lung adenocarcinomas of non-bronchioloalveolar type smaller than 30 mm. Staining results were evaluated semiquantitatively, and the expression of MUC1 and SP-A was compared in each case. There were 140/185 (76%) cases showing MUC1 expression higher than SP-A expression (MUC1>SP-A), and 45/185 (24%) cases showing MUC1 expression lower than or equal to SP-A expression (MUC1CONCLUSIONS:
A high MUC1/SP-A ratio is strongly associated with a poor outcome in patients with small-size lung adenocarcinoma.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Apoproteins
/
Adenocarcinoma
/
Biomarkers, Tumor
/
Mucin-1
/
Pulmonary Surfactant-Associated Proteins
/
Lung Neoplasms
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Histopathology
Year:
2004
Type:
Article
Affiliation country:
Japan