Caspase-11 mediates inflammatory dopaminergic cell death in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.

Furuya, Tsuyoshi; Hayakawa, Hideki; Yamada, Masanori; Yoshimi, Kenji; Hisahara, Shin; Miura, Masayuki; Mizuno, Yoshikuni; Mochizuki, Hideki

Furuya, Tsuyoshi; Hayakawa, Hideki; Yamada, Masanori; Yoshimi, Kenji; Hisahara, Shin; Miura, Masayuki; Mizuno, Yoshikuni; Mochizuki, Hideki.

Affiliation

Furuya T; Department of Neurology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.

J Neurosci ; 24(8): 1865-72, 2004 Feb 25.

Article in En | MEDLINE | ID: mdl-14985426

Subject(s)

Apoptosis/genetics; Caspases/metabolism; Dopamine/metabolism; Parkinsonian Disorders/physiopathology; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis/drug effects; Caspase Inhibitors; Caspases/genetics; Caspases, Initiator; Cell Count; Disease Models, Animal; Enzyme Inhibitors/pharmacology; Immunoblotting; Immunohistochemistry; Inflammation Mediators/metabolism; Interleukin-1/metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia/drug effects; Microglia/metabolism; Microglia/pathology; Neostriatum/drug effects; Neostriatum/pathology; Neurons/drug effects; Neurons/metabolism; Neurons/pathology; Nitric Oxide Synthase/drug effects; Nitric Oxide Synthase/metabolism; Nitric Oxide Synthase Type II; Parkinsonian Disorders/chemically induced; Parkinsonian Disorders/pathology; Substantia Nigra/drug effects; Substantia Nigra/pathology; Time Factors; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dopamine / Apoptosis / Caspases / Parkinsonian Disorders Type of study: Prognostic_studies Language: En Journal: J Neurosci Year: 2004 Type: Article Affiliation country: Japan

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