Increased susceptibility to experimental autoimmune neuritis after upregulation of the autoreactive T cell response to peripheral myelin antigen in apolipoprotein E-deficient mice.

Yu, Shuo; Duan, Rui-Sheng; Chen, Zhiguo; Quezada, Hernan Concha; Bao, Lei; Nennesmo, Inger; Zhu, Shun-Wei; Winblad, Bengt; Ljunggren, Hans-Gustaf; Zhu, Jie

Yu, Shuo; Duan, Rui-Sheng; Chen, Zhiguo; Quezada, Hernan Concha; Bao, Lei; Nennesmo, Inger; Zhu, Shun-Wei; Winblad, Bengt; Ljunggren, Hans-Gustaf; Zhu, Jie.

Affiliation

Yu S; Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.

J Neuropathol Exp Neurol ; 63(2): 120-8, 2004 Feb.

Article in En | MEDLINE | ID: mdl-14989598

Subject(s)

Apolipoproteins E/metabolism; Lymphocyte Activation/immunology; Myelin P0 Protein/metabolism; Neuritis, Autoimmune, Experimental/immunology; Neuritis, Autoimmune, Experimental/metabolism; T-Lymphocytes/immunology; Analysis of Variance; Animals; Antigens/metabolism; Apolipoproteins E/deficiency; Apolipoproteins E/genetics; Cell Count; Cytokines/metabolism; Disease Susceptibility; Enzyme-Linked Immunosorbent Assay/methods; Flow Cytometry/methods; Immunoglobulin G/analysis; Immunoglobulin G/metabolism; Immunohistochemistry/methods; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuritis, Autoimmune, Experimental/pathology; Neutrophil Infiltration; Peripheral Nerves/immunology; Peripheral Nerves/pathology; Spleen/cytology; Spleen/immunology; Spleen/metabolism; T-Lymphocytes/metabolism; Time Factors; Up-Regulation

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Collection: 01-internacional Database: MEDLINE Main subject: Apolipoproteins E / Lymphocyte Activation / T-Lymphocytes / Myelin P0 Protein / Neuritis, Autoimmune, Experimental Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neuropathol Exp Neurol Year: 2004 Type: Article Affiliation country: Sweden

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