Simultaneous quantification of cyclophosphamide, 4-hydroxycyclophosphamide, N,N',N"-triethylenethiophosphoramide (thiotepa) and N,N',N"-triethylenephosphoramide (tepa) in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

de Jonge, Milly E; van Dam, Selma M; Hillebrand, Michel J X; Rosing, Hilde; Huitema, Alwin D R; Rodenhuis, Sjoerd; Beijnen, Jos H

de Jonge, Milly E; van Dam, Selma M; Hillebrand, Michel J X; Rosing, Hilde; Huitema, Alwin D R; Rodenhuis, Sjoerd; Beijnen, Jos H.

Affiliation

de Jonge ME; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute/Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam, The Netherlands. apmil@slz.nl

J Mass Spectrom ; 39(3): 262-71, 2004 Mar.

Article in En | MEDLINE | ID: mdl-15039933

Subject(s)

Antineoplastic Agents, Alkylating/analysis; Chromatography, High Pressure Liquid/methods; Cyclophosphamide/analysis; Spectrometry, Mass, Electrospray Ionization/methods; Thiotepa/analysis; Triethylenephosphoramide/analysis; Antineoplastic Agents, Alkylating/blood; Chromatography, High Pressure Liquid/standards; Cyclophosphamide/blood; Drug Monitoring/instrumentation; Drug Monitoring/methods; Humans; Neoplasms/drug therapy; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization/standards; Thiotepa/blood; Triethylenephosphoramide/blood

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Collection: 01-internacional Database: MEDLINE Main subject: Triethylenephosphoramide / Chromatography, High Pressure Liquid / Thiotepa / Antineoplastic Agents, Alkylating / Cyclophosphamide / Spectrometry, Mass, Electrospray Ionization Type of study: Diagnostic_studies Limits: Humans Language: En Journal: J Mass Spectrom Year: 2004 Type: Article Affiliation country: Netherlands

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