Orally bioavailable small molecule ketoamide-based inhibitors of cathepsin K.

Barrett, David G; Catalano, John G; Deaton, David N; Long, Stacey T; Miller, Larry R; Tavares, Francis X; Wells-Knecht, Kevin J; Wright, Lois L; Zhou, Hui-Qiang Q

Barrett, David G; Catalano, John G; Deaton, David N; Long, Stacey T; Miller, Larry R; Tavares, Francis X; Wells-Knecht, Kevin J; Wright, Lois L; Zhou, Hui-Qiang Q.

Affiliation

Barrett DG; Department of Medicinal Chemistry, GlaxoSmithKline, Research Triangle Park, NC 27709, USA.

Bioorg Med Chem Lett ; 14(10): 2543-6, 2004 May 17.

Article in En | MEDLINE | ID: mdl-15109647

Subject(s)

Amides/chemical synthesis; Amides/pharmacology; Cathepsins/antagonists & inhibitors; Administration, Oral; Amides/administration & dosage; Animals; Biological Availability; Cathepsin K; Cell Line; Dogs; Humans; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Pharmacokinetics; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Cathepsins / Amides Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2004 Type: Article Affiliation country: United States

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