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Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K(ATP) channel openers: discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a potent K(ATP) opener that selectively inhibits spontaneous bladder contractions.
Carroll, William A; Altenbach, Robert J; Bai, Hao; Brioni, Jorge D; Brune, Michael E; Buckner, Steven A; Cassidy, Christopher; Chen, Yiyuan; Coghlan, Michael J; Daza, Anthony V; Drizin, Irene; Fey, Thomas A; Fitzgerald, Michael; Gopalakrishnan, Murali; Gregg, Robert J; Henry, Rodger F; Holladay, Mark W; King, Linda L; Kort, Michael E; Kym, Philip R; Milicic, Ivan; Tang, Rui; Turner, Sean C; Whiteaker, Kristi L; Yi, Lin; Zhang, Henry; Sullivan, James P.
Affiliation
  • Carroll WA; Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064-6101, USA. william.a.carroll@abbott.com
J Med Chem ; 47(12): 3163-79, 2004 Jun 03.
Article in En | MEDLINE | ID: mdl-15163196
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Collection: 01-internacional Database: MEDLINE Main subject: Urinary Bladder / Potassium Channels / Adenosine Triphosphate / Quinolones / Cyclic S-Oxides Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2004 Type: Article Affiliation country: United States
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Collection: 01-internacional Database: MEDLINE Main subject: Urinary Bladder / Potassium Channels / Adenosine Triphosphate / Quinolones / Cyclic S-Oxides Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2004 Type: Article Affiliation country: United States