Direct binding of hepatitis C virus core to gC1qR on CD4+ and CD8+ T cells leads to impaired activation of Lck and Akt.

Yao, Zhi Qiang; Eisen-Vandervelde, Audrey; Waggoner, Stephen N; Cale, Evan M; Hahn, Young S

Yao, Zhi Qiang; Eisen-Vandervelde, Audrey; Waggoner, Stephen N; Cale, Evan M; Hahn, Young S.

Affiliation

Yao ZQ; Department of Microbiology and Beirne Carter Center, University of Virginia, HSC Box 801386, Charlottesville, VA 22908, USA.

J Virol ; 78(12): 6409-19, 2004 Jun.

Article in En | MEDLINE | ID: mdl-15163734

Subject(s)

Hepacivirus/pathogenicity; Hyaluronan Receptors; Membrane Glycoproteins; Protein Serine-Threonine Kinases; Receptors, Complement/metabolism; Viral Core Proteins/metabolism; Amino Acid Sequence; Animals; Binding Sites; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Carrier Proteins; Cell Line; Guinea Pigs; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism; Mitochondrial Proteins; Molecular Sequence Data; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-akt; Transfection

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Receptors, Complement / Viral Core Proteins / Protein Serine-Threonine Kinases / Hepacivirus / Hyaluronan Receptors Limits: Animals / Humans Language: En Journal: J Virol Year: 2004 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google