Structure activity studies of ring E analogues of methyllycaconitine. Part 2: Synthesis of antagonists to the alpha3beta4* nicotinic acetylcholine receptors through modifications to the ester.

Bergmeier, Stephen C; Ismail, Khadiga A; Arason, Kristjan M; McKay, Susan; Bryant, Darrell L; McKay, Dennis B

Bergmeier, Stephen C; Ismail, Khadiga A; Arason, Kristjan M; McKay, Susan; Bryant, Darrell L; McKay, Dennis B.

Affiliation

Bergmeier SC; Department of Chemistry and Biochemistry, Ohio University, Athens, OH 45701, USA. bergmeis@ohio.edu

Bioorg Med Chem Lett ; 14(14): 3739-42, 2004 Jul 16.

Article in En | MEDLINE | ID: mdl-15203153

Subject(s)

Aconitine/analogs & derivatives; Aconitine/chemical synthesis; Nicotinic Antagonists/chemical synthesis; Receptors, Nicotinic/drug effects; Aconitine/pharmacology; Alkaloids/chemical synthesis; Alkaloids/pharmacology; Animals; Binding, Competitive/drug effects; Binding, Competitive/physiology; Catecholamines/metabolism; Cell Line; Diterpenes/chemical synthesis; Diterpenes/pharmacology; Esters/chemistry; Nicotinic Antagonists/pharmacology; Receptors, Nicotinic/metabolism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Aconitine / Receptors, Nicotinic / Nicotinic Antagonists Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2004 Type: Article Affiliation country: United States

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