Hydrophobic acetal and ketal derivatives of mannopeptimycin-alpha and desmethylhexahydromannopeptimycin-alpha: semisynthetic glycopeptides with potent activity against Gram-positive bacteria.

Dushin, Russell G; Wang, Ting-Zhong; Sum, Phaik-Eng; He, Haiyin; Sutherland, Alan G; Ashcroft, Joseph S; Graziani, Edmund I; Koehn, Frank E; Bradford, Patricia A; Petersen, Peter J; Wheless, Karen L; How, David; Torres, Nancy; Lenoy, Eileen B; Weiss, William J; Lang, Stanley A; Projan, Steven J; Shlaes, David M; Mansour, Tarek S

Dushin, Russell G; Wang, Ting-Zhong; Sum, Phaik-Eng; He, Haiyin; Sutherland, Alan G; Ashcroft, Joseph S; Graziani, Edmund I; Koehn, Frank E; Bradford, Patricia A; Petersen, Peter J; Wheless, Karen L; How, David; Torres, Nancy; Lenoy, Eileen B; Weiss, William J; Lang, Stanley A; Projan, Steven J; Shlaes, David M; Mansour, Tarek S.

Affiliation

Dushin RG; Wyeth Research, Chemical and Screening Sciences, Medicinal Chemistry, Pearl River, NY 10965, USA. dushinr@wyeth.com

J Med Chem ; 47(14): 3487-90, 2004 Jul 01.

Article in En | MEDLINE | ID: mdl-15214775

Subject(s)

Acetals/chemical synthesis; Anti-Bacterial Agents/chemical synthesis; Glycopeptides; Gram-Positive Bacteria/drug effects; Acetals/chemistry; Acetals/pharmacology; Anti-Bacterial Agents/chemistry; Anti-Bacterial Agents/pharmacology; Hydrophobic and Hydrophilic Interactions; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Glycopeptides / Gram-Positive Bacteria / Acetals / Anti-Bacterial Agents Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2004 Type: Article Affiliation country: United States

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