Synthesis and adrenoreceptor blocking action of aziridinium ions derived from phenoxybenzamine and dibenamine.

Henkel, J G; Portoghese, P S; Miller, J W; Lewis, P

Henkel, J G; Portoghese, P S; Miller, J W; Lewis, P.

J Med Chem ; 19(1): 6-10, 1976 Jan.

Article in En | MEDLINE | ID: mdl-1536

Subject(s)

Adrenergic alpha-Antagonists/chemical synthesis; Aziridines/chemical synthesis; Azirines/chemical synthesis; Dibenzylchlorethamine/analogs & derivatives; Phenoxybenzamine/analogs & derivatives; Animals; Aziridines/pharmacology; Cyclization; Dibenzylchlorethamine/chemical synthesis; Dibenzylchlorethamine/pharmacology; Hydrolysis; Kinetics; Male; Muscle Contraction/drug effects; Muscle, Smooth/drug effects; Phenoxybenzamine/chemical synthesis; Phenoxybenzamine/pharmacology; Rats; Vas Deferens/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Phenoxybenzamine / Aziridines / Azirines / Adrenergic alpha-Antagonists / Dibenzylchlorethamine Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1976 Type: Article

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