Converting trypsin to chymotrypsin: the role of surface loops.

Hedstrom, L; Szilagyi, L; Rutter, W J

Hedstrom, L; Szilagyi, L; Rutter, W J.

Affiliation

Hedstrom L; Hormone Research Institute, University of California, San Francisco 94143-0534.

Science ; 255(5049): 1249-53, 1992 Mar 06.

Article in En | MEDLINE | ID: mdl-1546324

Subject(s)

Chymotrypsin/chemistry; Trypsin/chemistry; Acylation; Amino Acid Sequence; Base Sequence; Binding Sites; Chymotrypsin/metabolism; Hydrolysis; Kinetics; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Protein Conformation; Substrate Specificity; Trypsin/genetics; Trypsin/metabolism

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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Chymotrypsin / Trypsin Language: En Journal: Science Year: 1992 Type: Article

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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Chymotrypsin / Trypsin Language: En Journal: Science Year: 1992 Type: Article