Grafts of immortalized chromaffin cells bio-engineered to improve met-enkephalin release also reduce formalin-evoked c-fos expression in rat spinal cord.

Duplan, H; Li, R Y; Vue, C; Zhou, H; Emorine, L; Herman, J P; Tafani, M; Lazorthes, Y; Eaton, M J

Duplan, H; Li, R Y; Vue, C; Zhou, H; Emorine, L; Herman, J P; Tafani, M; Lazorthes, Y; Eaton, M J.

Affiliation

Duplan H; Laboratoire Douleur et Therapie cellulaire, Faculte de Medecine Rangueil, 133 route de Narbonne, 31077 Toulouse, France.

Neurosci Lett ; 370(1): 1-6, 2004 Nov 03.

Article in En | MEDLINE | ID: mdl-15489007

Subject(s)

Chromaffin Cells/transplantation; Enkephalin, Methionine/metabolism; Formaldehyde/pharmacology; Pain/metabolism; Proto-Oncogene Proteins c-fos/metabolism; Spinal Cord/metabolism; Analysis of Variance; Animals; Cell Count/methods; Cell Line, Transformed; Chromaffin Cells/metabolism; Chromaffin Cells/physiology; Enkephalin, Methionine/genetics; Gene Expression Regulation/drug effects; Genetic Engineering; Graft Survival/physiology; Humans; Immunohistochemistry/methods; Male; Nerve Growth Factor/genetics; Nerve Growth Factor/metabolism; Pain/chemically induced; Phenylethanolamine N-Methyltransferase/metabolism; RNA, Messenger/biosynthesis; Radioimmunoassay/methods; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction/methods; Spinal Cord/drug effects; Transfection/methods

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Collection: 01-internacional Database: MEDLINE Main subject: Pain / Spinal Cord / Enkephalin, Methionine / Proto-Oncogene Proteins c-fos / Chromaffin Cells / Formaldehyde Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Neurosci Lett Year: 2004 Type: Article Affiliation country: France

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