Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding.

Hymowitz, Sarah G; Patel, Darshana R; Wallweber, Heidi J A; Runyon, Steven; Yan, Minhong; Yin, Jianping; Shriver, Stephanie K; Gordon, Nathaniel C; Pan, Borlan; Skelton, Nicholas J; Kelley, Robert F; Starovasnik, Melissa A

Hymowitz, Sarah G; Patel, Darshana R; Wallweber, Heidi J A; Runyon, Steven; Yan, Minhong; Yin, Jianping; Shriver, Stephanie K; Gordon, Nathaniel C; Pan, Borlan; Skelton, Nicholas J; Kelley, Robert F; Starovasnik, Melissa A.

Affiliation

Hymowitz SG; Department of Protein Engineering, Molecular Oncology, Medicinal Chemistry, and Immunology, Genentech, Inc., South San Francisco, California 94080, USA.

J Biol Chem ; 280(8): 7218-27, 2005 Feb 25.

Article in En | MEDLINE | ID: mdl-15542592

Subject(s)

Cysteine; Membrane Proteins/chemistry; Receptors, Tumor Necrosis Factor/chemistry; Tumor Necrosis Factor-alpha/chemistry; Alternative Splicing; Animals; B-Cell Activating Factor; B-Cell Maturation Antigen; Crystallization; Crystallography, X-Ray; Humans; Ligands; Membrane Proteins/genetics; Mice; Mutagenesis; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Structure, Tertiary; Receptors, Tumor Necrosis Factor/genetics; Signal Transduction; Solutions; Transmembrane Activator and CAML Interactor Protein; Tumor Necrosis Factor Ligand Superfamily Member 13

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Collection: 01-internacional Database: MEDLINE Main subject: Tumor Necrosis Factor-alpha / Receptors, Tumor Necrosis Factor / Cysteine / Membrane Proteins Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2005 Type: Article Affiliation country: United States

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