Mechanism of inhibition of human KSP by monastrol: insights from kinetic analysis and the effect of ionic strength on KSP inhibition.

Luo, Lusong; Carson, Jeffrey D; Dhanak, Dashyant; Jackson, Jeffrey R; Huang, Pearl S; Lee, Yan; Sakowicz, Roman; Copeland, Robert A

Luo, Lusong; Carson, Jeffrey D; Dhanak, Dashyant; Jackson, Jeffrey R; Huang, Pearl S; Lee, Yan; Sakowicz, Roman; Copeland, Robert A.

Affiliation

Luo L; Department of Enzymology and Mechanistic Pharmacology, MMPD CEDD, GlaxoSmithKline, Collegeville, Pennsylvania 19426, USA. lusong.luo@gsk.com

Biochemistry ; 43(48): 15258-66, 2004 Dec 07.

Article in En | MEDLINE | ID: mdl-15568818

Subject(s)

Kinesins/antagonists & inhibitors; Kinesins/chemistry; Pyrimidines/chemistry; Thiones/chemistry; Adenosine Diphosphate/metabolism; Adenosine Triphosphate/metabolism; Catalysis/drug effects; Catalytic Domain/drug effects; Dose-Response Relationship, Drug; Humans; Kinesins/metabolism; Kinetics; Microtubules/chemistry; Microtubules/drug effects; Microtubules/metabolism; Osmolar Concentration; Protein Binding/drug effects; Protein Conformation/drug effects; Pyrimidines/pharmacology; Spectrometry, Fluorescence; Thiones/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Thiones / Kinesins Limits: Humans Language: En Journal: Biochemistry Year: 2004 Type: Article Affiliation country: United States

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