Clinical-scale radiolabeling of a humanized anticarcinoembryonic antigen monoclonal antibody, hMN-14, with residualizing 131I for use in radioimmunotherapy.

Govindan, Serengulam V; Griffiths, Gary L; Stein, Rhona; Andrews, Philip; Sharkey, Robert M; Hansen, Hans J; Horak, Ivan D; Goldenberg, David M

Govindan, Serengulam V; Griffiths, Gary L; Stein, Rhona; Andrews, Philip; Sharkey, Robert M; Hansen, Hans J; Horak, Ivan D; Goldenberg, David M.

Affiliation

Govindan SV; Immunomedics, Inc., 300 American Rd., Morris Plains, NJ 07950, USA. sgovindan@immunomedics.com

J Nucl Med ; 46(1): 153-9, 2005 Jan.

Article in En | MEDLINE | ID: mdl-15632046

Subject(s)

Antibodies, Monoclonal/chemistry; Antibodies, Monoclonal/therapeutic use; Carcinoembryonic Antigen/chemistry; Carcinoembryonic Antigen/immunology; Isotope Labeling/methods; Oligopeptides/chemistry; Oligopeptides/therapeutic use; Pentetic Acid/analogs & derivatives; Radioimmunotherapy/methods; Radiopharmaceuticals/chemistry; Radiopharmaceuticals/therapeutic use; Antibodies, Monoclonal/isolation & purification; Antibodies, Monoclonal, Humanized; Carcinoembryonic Antigen/isolation & purification; Drug Stability; Humans; Oligopeptides/chemical synthesis; Oligopeptides/isolation & purification; Pentetic Acid/chemical synthesis; Pentetic Acid/chemistry; Pentetic Acid/isolation & purification; Pentetic Acid/therapeutic use; Radiopharmaceuticals/chemical synthesis; Radiopharmaceuticals/isolation & purification

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Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Carcinoembryonic Antigen / Radioimmunotherapy / Radiopharmaceuticals / Pentetic Acid / Isotope Labeling / Antibodies, Monoclonal Type of study: Evaluation_studies Limits: Humans Language: En Journal: J Nucl Med Year: 2005 Type: Article Affiliation country: United States

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