Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors.

Fitch, Richard W; Kaneko, Yumika; Klaperski, Paul; Daly, John W; Seitz, Gunther; Gündisch, Daniela

Fitch, Richard W; Kaneko, Yumika; Klaperski, Paul; Daly, John W; Seitz, Gunther; Gündisch, Daniela.

Affiliation

Fitch RW; Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.

Bioorg Med Chem Lett ; 15(4): 1221-4, 2005 Feb 15.

Article in En | MEDLINE | ID: mdl-15686946

Subject(s)

Alkaloids/chemical synthesis; Azocines/chemical synthesis; Quinolizines/chemical synthesis; Receptors, Nicotinic/metabolism; Alkaloids/pharmacology; Animals; Azocines/pharmacology; Calcium Signaling/drug effects; Cells, Cultured; Dose-Response Relationship, Drug; Halogens; Humans; Membrane Potentials/drug effects; Nicotinic Agonists; Protein Binding; Quinolizines/pharmacology; Rats; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Quinolizines / Azocines / Receptors, Nicotinic / Alkaloids Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2005 Type: Article Affiliation country: United States

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