Pharmacokinetic behavior of micafungin in rats with carbon tetrachloride-induced acute hepatic failure.
Biol Pharm Bull
; 28(3): 556-9, 2005 Mar.
Article
in En
| MEDLINE
| ID: mdl-15744091
ABSTRACT
We examined the pharmacokinetic behavior of micafungin, a novel antifungal agent, in rats receiving carbon tetrachloride (CCl4) at a single dose of 2.5 ml/kg. There was no significant change in the total clearance (CL(tot)) in CCl4-treated rats, while the steady-state volume of distribution (Vd(ss)) was significantly increased by CCl4 treatment. Alteration in the serum unbound fraction of micafungin after CCl4 treatment was unlikely in light of the serum albumin, bilirubin, creatinine, and urea nitrogen. The increased Vd(ss) was attributable to augmentation in the accessibility of micafungin to peripheral tissue without impairment of the intrinsic clearance, because slight enhancement of the tissue distribution of micafungin was confirmed following CCl4 treatment.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptides, Cyclic
/
Carbon Tetrachloride
/
Liver Failure, Acute
/
Lipoproteins
Limits:
Animals
Language:
En
Journal:
Biol Pharm Bull
Journal subject:
BIOQUIMICA
/
FARMACOLOGIA
Year:
2005
Type:
Article
Affiliation country:
Japan