ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.

Gumireddy, Kiranmai; Reddy, M V Ramana; Cosenza, Stephen C; Boominathan, R; Boomi Nathan, R; Baker, Stacey J; Papathi, Nabisa; Jiang, Jiandong; Holland, James; Reddy, E Premkumar

Gumireddy, Kiranmai; Reddy, M V Ramana; Cosenza, Stephen C; Boominathan, R; Boomi Nathan, R; Baker, Stacey J; Papathi, Nabisa; Jiang, Jiandong; Holland, James; Reddy, E Premkumar.

Affiliation

Gumireddy K; Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 N. Broad Street, Philadelphia, Pennsylvania 19140, USA.

Cancer Cell ; 7(3): 275-86, 2005 Mar.

Article in En | MEDLINE | ID: mdl-15766665

Subject(s)

Antineoplastic Agents/pharmacology; Cell Cycle Proteins/metabolism; Protein Kinase Inhibitors/pharmacology; Protein Kinases/metabolism; Proto-Oncogene Proteins/metabolism; Spindle Apparatus/drug effects; Adenosine Triphosphate/metabolism; Animals; Antineoplastic Agents/chemistry; Antineoplastic Agents/metabolism; Antineoplastic Agents/toxicity; Apoptosis; Cell Cycle/physiology; Cell Cycle Proteins/genetics; Cell Line, Tumor; Dose-Response Relationship, Drug; Female; Humans; Mice; Mice, Nude; Molecular Structure; Neoplasms, Experimental/metabolism; Protein Kinase Inhibitors/chemistry; Protein Kinase Inhibitors/metabolism; Protein Kinase Inhibitors/toxicity; Protein Kinases/genetics; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins/genetics; Spindle Apparatus/metabolism; Polo-Like Kinase 1

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Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinases / Proto-Oncogene Proteins / Cell Cycle Proteins / Protein Kinase Inhibitors / Spindle Apparatus / Antineoplastic Agents Limits: Animals / Female / Humans Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2005 Type: Article Affiliation country: United States

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