Transient cochlear ischemia and its effects on the stria vascularis.
Neuroreport
; 16(8): 799-802, 2005 May 31.
Article
in En
| MEDLINE
| ID: mdl-15891573
ABSTRACT
The effects of transient cochlear ischemia on the stria vascularis were studied. Fifteen minutes of ischemia decreased the endocochlear potential by up to 17.5 mV on day 1; it returned to normal on day 7. Immunostaining for Na+,K+-ATPase, a marker for the Na+/K+-pump, and for connexin 26, a marker for gap junctions, was inhibited on days 1 and 4, and returned to normal on day 7. Electron microscopy showed expansion of the intercellular space with abundant vacuolar formation in the stria vascularis. These morphological changes disappeared completely by day 7. The results indicate that transient ischemia causes a reversible functional disorder of the stria vascularis with fine structural changes, which may be owing to dysfunction of Na+/K+-pump or gap junctions.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stria Vascularis
/
Cochlear Diseases
/
Ischemic Attack, Transient
/
Cochlear Microphonic Potentials
Limits:
Animals
Language:
En
Journal:
Neuroreport
Journal subject:
NEUROLOGIA
Year:
2005
Type:
Article
Affiliation country:
Japan