Allosteric functioning of dimeric class C G-protein-coupled receptors.
FEBS J
; 272(12): 2947-55, 2005 Jun.
Article
in En
| MEDLINE
| ID: mdl-15955055
ABSTRACT
Whereas most membrane receptors are oligomeric entities, G-protein-coupled receptors have long been thought to function as monomers. Within the last 15 years, accumulating data have indicated that G-protein-coupled receptors can form dimers or even higher ordered oligomers, but the general functional significance of this phenomena is not yet clear. Among the large G-protein-coupled receptor family, class C receptors represent a well-recognized example of constitutive dimers, both subunits being linked, in most cases, by a disulfide bridge. In this review article, we show that class C G-protein-coupled receptors are multidomain proteins and highlight the importance of their dimerization for activation. We illustrate several consequences of this in terms of specific functional properties and drug development.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, G-Protein-Coupled
Limits:
Animals
/
Humans
Language:
En
Journal:
FEBS J
Journal subject:
BIOQUIMICA
Year:
2005
Type:
Article
Affiliation country:
France