Your browser doesn't support javascript.
loading
A chromosomally integrated bacteriophage in invasive meningococci.
Bille, Emmanuelle; Zahar, Jean-Ralph; Perrin, Agnes; Morelle, Sandrine; Kriz, Paula; Jolley, Keith A; Maiden, Martin C J; Dervin, Catherine; Nassif, Xavier; Tinsley, Colin R.
Affiliation
  • Bille E; Institut National de la Santé et de la Recherche Medicale U570, Faculté de Médecine Necker, 75015 Paris, France.
J Exp Med ; 201(12): 1905-13, 2005 Jun 20.
Article in En | MEDLINE | ID: mdl-15967821
Cerebrospinal meningitis is a feared disease that can cause the death of a previously healthy individual within hours. Paradoxically, the causative agent, Neisseria meningitidis, is a common inhabitant of the human nasopharynx, and as such, may be considered a normal, commensal organism. Only in a small proportion of colonized people do the bacteria invade the bloodstream, from where they can cross the blood-brain barrier to cause meningitis. Furthermore, most meningococcal disease is caused by bacteria belonging to only a few of the phylogenetic groups among the large number that constitute the population structure of this genetically variable organism. However, the genetic basis for the differences in pathogenic potential remains elusive. By performing whole genome comparisons of a large collection of meningococcal isolates of defined pathogenic potential we brought to light a meningococcal prophage present in disease-causing bacteria. The phage, of the filamentous family, excises from the chromosome and is secreted from the bacteria via the type IV pilin secretin. Therefore, this element, by spreading among the population, may promote the development of new epidemic clones of N. meningitidis that are capable of breaking the normal commensal relationship with humans and causing invasive disease.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inovirus / Prophages / Genomic Islands / Meningitis, Meningococcal / Neisseria meningitidis Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Exp Med Year: 2005 Type: Article Affiliation country: France

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inovirus / Prophages / Genomic Islands / Meningitis, Meningococcal / Neisseria meningitidis Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Exp Med Year: 2005 Type: Article Affiliation country: France