In islet-specific glucose-6-phosphatase-related protein, the beta cell antigenic sequence that is targeted in diabetes is not responsible for the loss of phosphohydrolase activity.

Shieh, J-J; Pan, C-J; Mansfield, B C; Chou, J Y

Shieh, J-J; Pan, C-J; Mansfield, B C; Chou, J Y.

Affiliation

Shieh JJ; Section on Cellular Differentiation, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1830, USA.

Diabetologia ; 48(9): 1851-9, 2005 Sep.

Article in En | MEDLINE | ID: mdl-16012821

Subject(s)

Glucose-6-Phosphatase/physiology; Islets of Langerhans/physiology; Phosphoric Monoester Hydrolases/metabolism; Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; COS Cells; Chlorocebus aethiops; Cloning, Molecular; Conserved Sequence; DNA Primers; Dogs; Glucose-6-Phosphatase/chemistry; Glucose-6-Phosphatase/genetics; Humans; Islets of Langerhans/enzymology; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Rats; Sequence Alignment; Sequence Homology, Amino Acid

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Collection: 01-internacional Database: MEDLINE Main subject: Islets of Langerhans / Glucose-6-Phosphatase / Phosphoric Monoester Hydrolases Limits: Animals / Humans Language: En Journal: Diabetologia Year: 2005 Type: Article Affiliation country: United States

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