Cytotoxicity, apoptosis induction, and mitotic arrest by a novel podophyllotoxin glucoside, 4DPG, in tumor cells.

Qi, Yi-lin; Liao, Fan; Zhao, Chang-qi; Lin, Yong-da; Zuo, Ming-xue

Qi, Yi-lin; Liao, Fan; Zhao, Chang-qi; Lin, Yong-da; Zuo, Ming-xue.

Affiliation

Qi YL; College of Life Sciences, Beijing Normal University, Beijing 100875, China.

Acta Pharmacol Sin ; 26(8): 1000-8, 2005 Aug.

Article in En | MEDLINE | ID: mdl-16038635

Subject(s)

Apoptosis/drug effects; Cell Division/drug effects; Cell Proliferation/drug effects; Glucosides/pharmacology; Podophyllotoxin/analogs & derivatives; Caspase 3; Caspases/metabolism; Cell Line, Tumor; Cell Nucleus/drug effects; Cell Nucleus/metabolism; Cell Nucleus/ultrastructure; DNA Fragmentation/drug effects; Dose-Response Relationship, Drug; Enzyme Activation/drug effects; Glucosides/chemistry; HeLa Cells; Humans; K562 Cells; Microscopy, Electron, Transmission; Microtubules/drug effects; Microtubules/metabolism; Molecular Structure; Podophyllotoxin/chemistry; Podophyllotoxin/pharmacology; Polymers/metabolism; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Podophyllotoxin / Cell Division / Apoptosis / Cell Proliferation / Glucosides Limits: Humans Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2005 Type: Article Affiliation country: China

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