Allogeneic hemopoietic stem cell transplantation in solid tumors.
Transplant Proc
; 37(6): 2664-6, 2005.
Article
in En
| MEDLINE
| ID: mdl-16182778
ABSTRACT
The existence of a graft versus tumor (GVT) effect of donor-derived T cells after allogeneic hematopoietic stem cell transplantation is well established as a critical component for the success of the procedure in several hematologic malignancies. Although it has been suggested that a GVT effect might also be generated in patients affected by refractory solid tumors, the morbidity of conventional allogeneic hematopoietic stem cell transplantation has limited its investigation in these diseases. Recently introduced allogeneic nonmyeloablative regimens have greatly decreased morbidity and mortality related to transplants which retain a powerful GVT. On this basis, it has become possible to explore the existence of alloreactivity toward solid tumors. The present article reviews the early clinical results of this novel immunotherapeutic approach for solid tumors.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transplantation, Homologous
/
Stem Cell Transplantation
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Transplant Proc
Year:
2005
Type:
Article
Affiliation country:
Italy