Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma.

Attia, Peter; Maker, Ajay V; Haworth, Leah R; Rogers-Freezer, Linda; Rosenberg, Steven A

Attia, Peter; Maker, Ajay V; Haworth, Leah R; Rogers-Freezer, Linda; Rosenberg, Steven A.

Affiliation

Attia P; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1201, USA.

J Immunother ; 28(6): 582-92, 2005.

Article in En | MEDLINE | ID: mdl-16224276

Subject(s)

Antineoplastic Agents/therapeutic use; Diphtheria Toxin/therapeutic use; Interleukin-2/therapeutic use; Melanoma/drug therapy; Skin Neoplasms/drug therapy; T-Lymphocytes, Regulatory/drug effects; Adult; Antineoplastic Agents/administration & dosage; CD8-Positive T-Lymphocytes/drug effects; CD8-Positive T-Lymphocytes/immunology; Carcinoma, Renal Cell/drug therapy; Carcinoma, Renal Cell/immunology; Carcinoma, Renal Cell/secondary; Cell Line, Tumor; Female; Forkhead Transcription Factors/genetics; Forkhead Transcription Factors/metabolism; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms/drug therapy; Kidney Neoplasms/immunology; Kidney Neoplasms/pathology; Male; Melanoma/immunology; Melanoma/secondary; Middle Aged; Neoplasm Metastasis; RNA, Messenger/metabolism; Receptors, Interleukin-2/immunology; Recombinant Fusion Proteins/therapeutic use; Skin Neoplasms/immunology; Skin Neoplasms/secondary; T-Lymphocytes, Regulatory/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Interleukin-2 / T-Lymphocytes, Regulatory / Diphtheria Toxin / Melanoma / Antineoplastic Agents Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: J Immunother Journal subject: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Year: 2005 Type: Article Affiliation country: United States

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