L-nucleosides containing modified nucleobases.

Seela, Frank; Lin, W; Kazimierczuk, Z; Rosemeyer, H; Glaron, V; Peng, X; He, Y; Ming, X; Andrzejewska, M; Gorska, A; Zhang, X; Eickmeier, H; La Colla, P

Seela, Frank; Lin, W; Kazimierczuk, Z; Rosemeyer, H; Glaron, V; Peng, X; He, Y; Ming, X; Andrzejewska, M; Gorska, A; Zhang, X; Eickmeier, H; La Colla, P.

Affiliation

Seela F; Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Germany.

Nucleosides Nucleotides Nucleic Acids ; 24(5-7): 859-63, 2005.

Article in En | MEDLINE | ID: mdl-16248050

ABSTRACT

ABSTRACT

The synthesis of base modified L-nucleosides is described with pyrrolo[2,3-d]pyrimidines, pyrazolo[3,4-d]pyrimidines, benzimidazoles, and imidazo[1,2-a]-s-triazines as nucleobases. The conformation of the nucleosides is studied and the antiviral activity is evaluated.

Subject(s)

Nucleosides/chemistry; Pyrimidines/chemistry; Antiviral Agents/pharmacology; Base Composition; Benzimidazoles/chemistry; Chemistry, Pharmaceutical/methods; Crystallography, X-Ray; Drug Design; Glycosylation; Models, Chemical; Molecular Biology/methods; Molecular Conformation; Nucleic Acid Conformation; Purines/chemistry; Triazines/chemistry; X-Rays

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Nucleosides Language: En Journal: Nucleosides Nucleotides Nucleic Acids Journal subject: BIOQUIMICA Year: 2005 Type: Article Affiliation country: Germany

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