Dipeptide-based highly potent doxorubicin antibody conjugates.

Jeffrey, Scott C; Nguyen, Minh T; Andreyka, Jamie B; Meyer, Damon L; Doronina, Svetlana O; Senter, Peter D

Jeffrey, Scott C; Nguyen, Minh T; Andreyka, Jamie B; Meyer, Damon L; Doronina, Svetlana O; Senter, Peter D.

Affiliation

Jeffrey SC; Department of Chemistry, Seattle Genetics, 21823 30th Drive SE, Bothell, WA 98021, USA. sjeffrey@seagen.com

Bioorg Med Chem Lett ; 16(2): 358-62, 2006 Jan 15.

Article in En | MEDLINE | ID: mdl-16275070

Subject(s)

Carcinoma, Renal Cell/drug therapy; Dipeptides/chemistry; Doxorubicin/chemistry; Immunotoxins/chemistry; Immunotoxins/pharmacology; Lymphoma, Large B-Cell, Diffuse/drug therapy; Antigens, Neoplasm/drug effects; Antigens, Neoplasm/immunology; Binding Sites; Cell Line, Tumor; Doxorubicin/analogs & derivatives; Drug Delivery Systems/methods; Drug Screening Assays, Antitumor; Drug Stability; Humans; Hydrolysis; Molecular Conformation; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Renal Cell / Doxorubicin / Immunotoxins / Lymphoma, Large B-Cell, Diffuse / Dipeptides Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2006 Type: Article Affiliation country: United States

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