Role of surfactant protein D (SP-D) in innate immunity in the gastric mucosa: evidence of interaction with Helicobacter pylori lipopolysaccharide.
J Endotoxin Res
; 11(6): 357-62, 2005.
Article
in En
| MEDLINE
| ID: mdl-16303091
ABSTRACT
Surfactant protein D (SP-D) is a collagenous glycoprotein, a collectin, which functions as a pathogen-associated molecular pattern (PAMP) recognition receptor in the innate immune response. Although originally identified in the lung as a component of surfactant, SP-D also occurs in the gastric mucosa at the luminal surface and within gastric pits of mucus-secreting cells. Infection with the gastroduodenal pathogen Helicobacter pylori up-regulates expression of SP-D in human patients with gastritis, and its influence on colonization has been demonstrated in a Helicobacter SP-D-deficient (SP-D(-/-)) mouse model. SP-D binds and agglutinates H. pylori cells in a lectin-specific manner, and has been shown to bind H. pylori lipopolysaccharide. Furthermore, evidence indicates that H. pylori varies LPS O-chain structure to evade SP-D binding which is speculated aids persistence of this chronic infection.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lipopolysaccharides
/
Helicobacter pylori
/
Pulmonary Surfactant-Associated Protein D
/
Gastric Mucosa
/
Immunity, Innate
Language:
En
Journal:
J Endotoxin Res
Journal subject:
ANGIOLOGIA
/
BACTERIOLOGIA
Year:
2005
Type:
Article
Affiliation country:
Ireland