Embryonic stem cells in predictive cardiotoxicity: laser capture microscopy enables assay development.

Chaudhary, Khuram W; Barrezueta, Nestor X; Bauchmann, Mary B; Milici, Anthony J; Beckius, Gretchen; Stedman, Donald B; Hambor, John E; Blake, William L; McNeish, John D; Bahinski, Anthony; Cezar, Gabriela Gebrin

Chaudhary, Khuram W; Barrezueta, Nestor X; Bauchmann, Mary B; Milici, Anthony J; Beckius, Gretchen; Stedman, Donald B; Hambor, John E; Blake, William L; McNeish, John D; Bahinski, Anthony; Cezar, Gabriela Gebrin.

Affiliation

Chaudhary KW; Pfizer Global Research and Development, Chesterfield, Missouri 63017, USA.

Toxicol Sci ; 90(1): 149-58, 2006 Mar.

Article in En | MEDLINE | ID: mdl-16357009

Subject(s)

Heart Diseases/chemically induced; Microscopy, Confocal/methods; Myocytes, Cardiac/drug effects; Stem Cells/drug effects; Xenobiotics/toxicity; Animals; Biological Assay/methods; Biomarkers/metabolism; Calcium/metabolism; Calcium/pharmacology; Cells, Cultured; Drug Evaluation, Preclinical/methods; Fetal Heart/cytology; Gene Expression Profiling; Gene Expression Regulation/drug effects; Heart Diseases/pathology; Lasers; Mice; Mice, Inbred DBA; Microdissection/methods; Myocytes, Cardiac/metabolism; Myocytes, Cardiac/pathology; Nifedipine/pharmacology; Oligonucleotide Array Sequence Analysis; Stem Cells/metabolism; Stem Cells/pathology

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Collection: 01-internacional Database: MEDLINE Main subject: Stem Cells / Xenobiotics / Microscopy, Confocal / Myocytes, Cardiac / Heart Diseases Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2006 Type: Article Affiliation country: United States

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