O6-(4-bromothenyl)guanine (PaTrin-2), a novel inhibitor of O6-alkylguanine DNA alkyl-transferase, increases the inhibitory activity of temozolomide against human acute leukaemia cells in vitro.

Turriziani, M; Caporaso, P; Bonmassar, L; Buccisano, F; Amadori, S; Venditti, A; Cantonetti, M; D'Atri, S; Bonmassar, E

Turriziani, M; Caporaso, P; Bonmassar, L; Buccisano, F; Amadori, S; Venditti, A; Cantonetti, M; D'Atri, S; Bonmassar, E.

Affiliation

Turriziani M; Department of Internal Medicine, University of Rome "Tor Vergata", School of Medicine, via Montpellier 1, Rome, Italy.

Pharmacol Res ; 53(4): 317-23, 2006 Apr.

Article in En | MEDLINE | ID: mdl-16412662

Subject(s)

Antineoplastic Agents, Alkylating/pharmacology; Antineoplastic Combined Chemotherapy Protocols/pharmacology; Dacarbazine/analogs & derivatives; Guanine/analogs & derivatives; Leukemia, Myeloid/drug therapy; O(6)-Methylguanine-DNA Methyltransferase/antagonists & inhibitors; Acute Disease; Dacarbazine/pharmacology; Drug Synergism; Guanine/pharmacology; HL-60 Cells; Humans; Leukemia, Myeloid/blood; Leukemia, Myeloid/enzymology; Leukemia, Myeloid/pathology; Leukocytes, Mononuclear/drug effects; Leukocytes, Mononuclear/pathology; Temozolomide; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Leukemia, Myeloid / Antineoplastic Agents, Alkylating / O(6)-Methylguanine-DNA Methyltransferase / Dacarbazine / Guanine Type of study: Guideline Limits: Humans Language: En Journal: Pharmacol Res Journal subject: FARMACOLOGIA Year: 2006 Type: Article Affiliation country: Italy

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