Interleukin-8 CSF levels predict survival in patients with leptomeningeal metastases.
Neurology
; 66(2): 243-6, 2006 Jan 24.
Article
in En
| MEDLINE
| ID: mdl-16434663
ABSTRACT
Median survival of patients with leptomeningeal metastases (LM) is 4 to 6 months, with a few long-term survivors. Current prognostic factors for survival have limited value. The authors measured the CSF levels of nine inflammatory proteins in 57 patients with LM and determined their prognostic value. High interleukin (IL)-8 CSF levels predicted short-term survival independently. The data indicate that IL-8 CSF levels may serve as a prognosticator in patients with LM, but prospective validation is needed.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arachnoid
/
Pia Mater
/
Interleukin-8
/
Survivors
/
Meningeal Neoplasms
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Neurology
Year:
2006
Type:
Article
Affiliation country:
Netherlands