Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents.

Monk, Keith A; Siles, Rogelio; Hadimani, Mallinath B; Mugabe, Benon E; Ackley, J Freeland; Studerus, Scott W; Edvardsen, Klaus; Trawick, Mary Lynn; Garner, Charles M; Rhodes, Monte R; Pettit, George R; Pinney, Kevin G

Monk, Keith A; Siles, Rogelio; Hadimani, Mallinath B; Mugabe, Benon E; Ackley, J Freeland; Studerus, Scott W; Edvardsen, Klaus; Trawick, Mary Lynn; Garner, Charles M; Rhodes, Monte R; Pettit, George R; Pinney, Kevin G.

Affiliation

Monk KA; Baylor University, Department of Chemistry and Biochemistry and The Center for Drug Discovery, One Bear Place # 97348, Waco, TX 76798, USA.

Bioorg Med Chem ; 14(9): 3231-44, 2006 May 01.

Article in En | MEDLINE | ID: mdl-16442292

Subject(s)

Bibenzyls/chemistry; Bibenzyls/pharmacology; Drug Design; Stilbenes/chemistry; Stilbenes/pharmacology; Tubulin/metabolism; Animals; Benzaldehydes/chemistry; Bibenzyls/chemical synthesis; Bibenzyls/toxicity; Cattle; Cell Proliferation/drug effects; Isomerism; Mice; Molecular Structure; Neoplasms/blood supply; Regional Blood Flow/drug effects; Stilbenes/chemical synthesis; Stilbenes/toxicity; Structure-Activity Relationship; Xenograft Model Antitumor Assays

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Collection: 01-internacional Database: MEDLINE Main subject: Stilbenes / Tubulin / Bibenzyls / Drug Design Limits: Animals Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2006 Type: Article Affiliation country: United States

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