Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.

Sieber, O M; Segditsas, S; Knudsen, A L; Zhang, J; Luz, J; Rowan, A J; Spain, S L; Thirlwell, C; Howarth, K M; Jaeger, E E M; Robinson, J; Volikos, E; Silver, A; Kelly, G; Aretz, S; Frayling, I; Hutter, P; Dunlop, M; Guenther, T; Neale, K; Phillips, R; Heinimann, K; Tomlinson, I P M

Sieber, O M; Segditsas, S; Knudsen, A L; Zhang, J; Luz, J; Rowan, A J; Spain, S L; Thirlwell, C; Howarth, K M; Jaeger, E E M; Robinson, J; Volikos, E; Silver, A; Kelly, G; Aretz, S; Frayling, I; Hutter, P; Dunlop, M; Guenther, T; Neale, K; Phillips, R; Heinimann, K; Tomlinson, I P M.

Affiliation

Sieber OM; Molecular and Population Genetics Laboratory, Cancer Research UK, London Research Institute, London, UK.

Gut ; 55(10): 1440-8, 2006 Oct.

Article in En | MEDLINE | ID: mdl-16461775

Subject(s)

Adenomatous Polyposis Coli/genetics; Germ-Line Mutation/genetics; Adenomatous Polyposis Coli Protein/genetics; Adult; Aged; DNA Mutational Analysis; Exons; Female; Humans; Loss of Heterozygosity; Male; Middle Aged; Phenotype; Polymorphism, Single Nucleotide

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Germ-Line Mutation / Adenomatous Polyposis Coli Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Gut Year: 2006 Type: Article Affiliation country: United kingdom

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