Negative cell cycle regulator 14-3-3sigma stabilizes p27 Kip1 by inhibiting the activity of PKB/Akt.

Yang, H; Zhang, Y; Zhao, R; Wen, Y-Y; Fournier, K; Wu, H-B; Yang, H-Y; Diaz, J; Laronga, C; Lee, M-H

Yang, H; Zhang, Y; Zhao, R; Wen, Y-Y; Fournier, K; Wu, H-B; Yang, H-Y; Diaz, J; Laronga, C; Lee, M-H.

Affiliation

Yang H; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Oncogene ; 25(33): 4585-94, 2006 Aug 03.

Article in En | MEDLINE | ID: mdl-16532026

Subject(s)

Biomarkers, Tumor/metabolism; Cyclin-Dependent Kinase Inhibitor p27/metabolism; Exonucleases/metabolism; Gene Expression Regulation, Neoplastic; Neoplasm Proteins/metabolism; Proto-Oncogene Proteins c-akt/metabolism; 14-3-3 Proteins; Animals; Antineoplastic Agents/pharmacology; Apoptosis; Cell Line, Tumor; Epithelial Cells/metabolism; Exoribonucleases; Female; Humans; Mice; Mice, Nude; Mink; Rats

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Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers, Tumor / Gene Expression Regulation, Neoplastic / Proto-Oncogene Proteins c-akt / Cyclin-Dependent Kinase Inhibitor p27 / Exonucleases / Neoplasm Proteins Limits: Animals / Female / Humans Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2006 Type: Article Affiliation country: United States

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