Antidepressant-like effects of PDE4 inhibitors mediated by the high-affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in rats.

Zhang, Han-Ting; Zhao, Yu; Huang, Ying; Deng, Chengjun; Hopper, Allen T; De Vivo, Michael; Rose, Gregory M; O'Donnell, James M

Zhang, Han-Ting; Zhao, Yu; Huang, Ying; Deng, Chengjun; Hopper, Allen T; De Vivo, Michael; Rose, Gregory M; O'Donnell, James M.

Affiliation

Zhang HT; Departments of Behavioral Medicine & Psychiatry and Neurobiology & Anatomy, West Virginia University Health Sciences Center, Morgantown, WV 26506, USA. hzhang@hsc.wvu.edu

Psychopharmacology (Berl) ; 186(2): 209-17, 2006 Jun.

Article in En | MEDLINE | ID: mdl-16586089

Subject(s)

3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors; Antidepressive Agents/pharmacology; Behavior, Animal/drug effects; Phosphodiesterase Inhibitors/pharmacology; Rolipram/pharmacology; Animals; Binding, Competitive; Cyclic Nucleotide Phosphodiesterases, Type 4; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / Behavior, Animal / 3',5'-Cyclic-AMP Phosphodiesterases / Rolipram / Antidepressive Agents Limits: Animals Language: En Journal: Psychopharmacology (Berl) Year: 2006 Type: Article Affiliation country: United States

Search on Google

XML

PubMed Links