Cancer and blood coagulation.
Cell Mol Life Sci
; 63(9): 1024-7, 2006 May.
Article
in En
| MEDLINE
| ID: mdl-16612563
ABSTRACT
In human patients, blood coagulation disorders often associate with cancer, even in its early stages. Recently, in vitro and in vivo experimental models have shown that oncogene expression, or inactivation of tumour suppressor genes, upregulate genes that control blood coagulation. These studies suggest that activation of blood clotting, leading to peritumoral fibrin deposition, is instrumental in cancer development. Fibrin can indeed build up a provisional matrix, supporting the invasive growth of neoplastic tissues and blood vessels. Interference with blood coagulation can thus be considered as part of a multifaceted therapeutic approach to cancer.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Coagulation
/
Gene Expression Regulation, Neoplastic
/
Models, Genetic
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Cell Mol Life Sci
Journal subject:
BIOLOGIA MOLECULAR
Year:
2006
Type:
Article
Affiliation country:
Italy