A mechanism for the inactivation of Ca2+/calmodulin-dependent protein kinase II during prolonged seizure activity and its consequence after the recovery from seizure activity in rats in vivo.

Yamagata, Y; Imoto, K; Obata, K

Yamagata, Y; Imoto, K; Obata, K.

Affiliation

Yamagata Y; Laboratory of Neurochemistry National Institute for Physiological Sciences, Myodaiji, Okazaki 444-8787, Japan. yamagata@nips.ac.jp

Neuroscience ; 140(3): 981-92, 2006 Jul 07.

Article in En | MEDLINE | ID: mdl-16632208

Subject(s)

Brain/enzymology; Calcium Signaling/physiology; Calcium-Calmodulin-Dependent Protein Kinases/metabolism; Calcium/metabolism; Epilepsy/enzymology; Recovery of Function/physiology; Animals; Brain/drug effects; Brain/physiopathology; Calcium Signaling/drug effects; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Membrane/drug effects; Cell Membrane/metabolism; Convulsants/pharmacology; Disease Models, Animal; Enzyme Activation/drug effects; Enzyme Activation/physiology; Epilepsy/chemically induced; Epilepsy/physiopathology; Kainic Acid/pharmacology; Male; Membrane Potentials/drug effects; Membrane Potentials/physiology; Neurons/drug effects; Neurons/metabolism; Phosphorylation/drug effects; Rats; Rats, Wistar; Recovery of Function/drug effects; Solubility; Status Epilepticus/chemically induced; Status Epilepticus/enzymology; Status Epilepticus/physiopathology; Threonine/metabolism

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Brain / Calcium / Calcium-Calmodulin-Dependent Protein Kinases / Recovery of Function / Calcium Signaling / Epilepsy Type of study: Prognostic_studies Limits: Animals Language: En Journal: Neuroscience Year: 2006 Type: Article Affiliation country: Japan

Search on Google

XML

PubMed Links