Does topical application of 5-fluorouracil ointment influence inner ear function?
Otolaryngol Head Neck Surg
; 134(6): 961-5, 2006 Jun.
Article
in En
| MEDLINE
| ID: mdl-16730538
ABSTRACT
OBJECTIVE:
To investigate the effect of 5-fluorouracil (5-FU) ointment on the inner ear of guinea pigs. STUDY DESIGN ANDSETTING:
In group A (n = 7), 5-FU ointment was applied into the left external auditory canal. In group B (n = 10), 5-FU ointment was applied to the left middle ear through myringotomy. In both groups, the right ear served as a control. One week later the endocochlear DC potential (EP) was measured and morphology of the cochleae was examined using scanning electron microscopy (SEM) and light microscopy.RESULTS:
In group A, there was no significant difference between the EP values of the experimental side and the control side. In group B, there was a statistically significant difference between them (P < 0.05). Morphologic findings showed no damage.CONCLUSION:
5-FU ointment application to the external ear seems to be safe but its application to the middle ear may pose some risk of ototoxicity.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fluorouracil
/
Ear, Inner
/
Antimetabolites, Antineoplastic
Limits:
Animals
Language:
En
Journal:
Otolaryngol Head Neck Surg
Year:
2006
Type:
Article
Affiliation country:
Japan