Design and synthesis of potent and selective 1,3,4-trisubstituted-2-oxopiperazine based melanocortin-4 receptor agonists.

Tian, Xinrong; Mishra, Rajesh K; Switzer, Adrian G; Hu, X Eric; Kim, Nick; Mazur, Adam W; Ebetino, Frank H; Wos, John A; Crossdoersen, Doreen; Pinney, Beth B; Farmer, Julie A; Sheldon, Russell J

Tian, Xinrong; Mishra, Rajesh K; Switzer, Adrian G; Hu, X Eric; Kim, Nick; Mazur, Adam W; Ebetino, Frank H; Wos, John A; Crossdoersen, Doreen; Pinney, Beth B; Farmer, Julie A; Sheldon, Russell J.

Affiliation

Tian X; Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA. tian.x@hotmail.com

Bioorg Med Chem Lett ; 16(17): 4668-73, 2006 Sep 01.

Article in En | MEDLINE | ID: mdl-16766182

Subject(s)

Drug Design; Guanidines/chemistry; Guanidines/pharmacology; Piperazines/chemistry; Piperazines/pharmacology; Receptor, Melanocortin, Type 4/agonists; Guanidines/chemical synthesis; Molecular Structure; Piperazines/chemical synthesis; Receptor, Melanocortin, Type 4/metabolism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Drug Design / Receptor, Melanocortin, Type 4 / Guanidines Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2006 Type: Article Affiliation country: United States

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