Clinical efficacy of intravenous colistin therapy in combination with ceftazidime in severe MDR P. aeruginosa systemic infections in two haematological patients.

Tascini, C; Menichetti, F; Stefanelli, A; Loni, C; Lambelet, P

Tascini, C; Menichetti, F; Stefanelli, A; Loni, C; Lambelet, P.

Affiliation

Tascini C; Infectious Diseases Unit, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.

Infez Med ; 14(1): 41-4, 2006 Mar.

Article in En | MEDLINE | ID: mdl-16794379

ABSTRACT

ABSTRACT

Nosocomial infections due to MDR P. aeruginosa are an increasing problem. Therapeutical options are few. We describe two haematological patients with severe neutropenia and systemic infection due to MDR P. aeruginosa treated successfully with colistin plus ceftazidime. Severe adverse events were not described.

Subject(s)

Bacteremia/drug therapy; Ceftazidime/therapeutic use; Colistin/therapeutic use; Leukemia, Myeloid/complications; Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications; Pseudomonas Infections/drug therapy; Acute Disease; Adrenal Cortex Hormones/adverse effects; Adrenal Cortex Hormones/therapeutic use; Aged; Anemia, Refractory, with Excess of Blasts/complications; Anti-Bacterial Agents/therapeutic use; Antineoplastic Combined Chemotherapy Protocols/adverse effects; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Bacteremia/etiology; Ceftazidime/administration & dosage; Colistin/administration & dosage; Colitis/etiology; Colitis/surgery; Disease Susceptibility; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Fatal Outcome; Female; Humans; Infusions, Intravenous; Leukemia, Myeloid/drug therapy; Lymphoma, Non-Hodgkin/drug therapy; Lymphoma, Non-Hodgkin/radiotherapy; Male; Middle Aged; Neoplasms, Second Primary/complications; Peritonitis/etiology; Postoperative Complications/etiology; Postoperative Complications/microbiology; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy; Pseudomonas Infections/etiology; Radiation Injuries/etiology; Radiation Injuries/surgery; Spinal Neoplasms/drug therapy; Spinal Neoplasms/radiotherapy; Typhlitis/complications

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Collection: 01-internacional Database: MEDLINE Main subject: Pseudomonas Infections / Leukemia, Myeloid / Ceftazidime / Bacteremia / Colistin / Precursor Cell Lymphoblastic Leukemia-Lymphoma Type of study: Etiology_studies Language: En Journal: Infez Med Journal subject: ALERGIA E IMUNOLOGIA Year: 2006 Type: Article Affiliation country: Italy

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