Molecular structures of coat and coat-associated proteins: function follows form.
Curr Opin Cell Biol
; 18(4): 395-406, 2006 Aug.
Article
in En
| MEDLINE
| ID: mdl-16806884
ABSTRACT
Endocytic clathrin-coated vesicles arise through the deformation of a small region of plasma membrane encapsulated by a cytosol-oriented clathrin lattice. The coat assembles from soluble protomers in a rapid and highly cooperative process, and invagination is tightly linked to the selective enrichment of cargo molecules within the nascent bud. Recent structural and functional studies demonstrate that coat assembly, membrane deformation, local actin dynamics and the final scission event are intricately coupled, and begin to reveal how key multifunctional, modular proteins are responsible for this linkage. An emerging mechanistic theme is how sequential engagement of common interaction surfaces or network hubs can evict prior binding partners from the assembly zone to ensure vectorial progression of the coat assembly process.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proteins
/
Clathrin-Coated Vesicles
Type of study:
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
Curr Opin Cell Biol
Year:
2006
Type:
Article
Affiliation country:
United States