[Circulating proteinic biomarkers and breast cancer]. / Marqueurs protéiques circulants et cancer du sein.
Gynecol Obstet Fertil
; 34(7-8): 638-46, 2006.
Article
in Fr
| MEDLINE
| ID: mdl-16876456
ABSTRACT
Circulating proteinic biomarkers are secreted by tumor cells or by their environmental cells and they have a variable specificity. In case of breast cancer, carcino-embryonic antigen (CEA) was for a long time the only circulating biomarker used. Nowadays, the most useful biomarkers measure circulating levels of fragments of MUC1-polymorphic epithelial mucin (MUC1-PEM) cancer antigen (CA) 15.3, mucin-like carcinoma-associated antigen (MCA), CA 27-29, CA 549... They are useful for general disease follow-up. Other circulating markers belonging to keratins (tissue polypeptide antigen, TPA, TPS or Cyfra 21.1) are correlated with proliferative activity of breast tumors. More recently, the measure of the c-erb B2 circulating part (extra cellular domain, ECD) was proposed as a prognostic biomarker for breast tumors with c-erb B2 overexpression. Moreover, the determination of urinary level of trefoil factor1 (PS2-TFF1) might be useful for the follow-up of hormonodependent breast cancers. The present review describes the clinical interest of these different circulating biomarkers in case of breast cancer, emphasizing their biological characteristics.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Biomarkers, Tumor
/
Neoplasm Proteins
Type of study:
Prognostic_studies
Limits:
Female
/
Humans
Language:
Fr
Journal:
Gynecol Obstet Fertil
Journal subject:
GINECOLOGIA
/
OBSTETRICIA
Year:
2006
Type:
Article
Affiliation country:
France