Estrogen modulates in vitro atrial bradycardia induced by Indian red scorpion venom via G-protein coupled mechanisms.

Alex, Anitha B; Kanoo, Sadhana; Deshpande, Shripad B

Alex, Anitha B; Kanoo, Sadhana; Deshpande, Shripad B.

Affiliation

Alex AB; Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221 005, India.

Eur J Pharmacol ; 546(1-3): 102-8, 2006 Sep 28.

Article in En | MEDLINE | ID: mdl-16876782

Subject(s)

Anti-Arrhythmia Agents/pharmacology; Bradycardia/prevention & control; Estrogens/pharmacology; GTP-Binding Protein alpha Subunits, Gi-Go/drug effects; Heart Atria/drug effects; Receptors, Estrogen/drug effects; Scorpion Venoms/toxicity; Animals; Anti-Arrhythmia Agents/therapeutic use; Atropine/pharmacology; Bradycardia/chemically induced; Bradycardia/physiopathology; Dose-Response Relationship, Drug; Enzyme Inhibitors/pharmacology; Estrogen Antagonists/pharmacology; Estrogens/therapeutic use; Female; GTP-Binding Protein alpha Subunits, Gi-Go/metabolism; Guanylate Cyclase/antagonists & inhibitors; Heart Atria/metabolism; Heart Rate/drug effects; In Vitro Techniques; Male; Methylene Blue/pharmacology; Muscarinic Antagonists/pharmacology; Myocardial Contraction/drug effects; Orchiectomy; Pertussis Toxin/pharmacology; Rats; Receptors, Estrogen/metabolism; Sex Factors; Tamoxifen/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Scorpion Venoms / Bradycardia / Receptors, Estrogen / GTP-Binding Protein alpha Subunits, Gi-Go / Estrogens / Heart Atria / Anti-Arrhythmia Agents Limits: Animals Language: En Journal: Eur J Pharmacol Year: 2006 Type: Article Affiliation country: India

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