Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats.

Oelze, Matthias; Daiber, Andreas; Brandes, Ralf P; Hortmann, Marcus; Wenzel, Philip; Hink, Ulrich; Schulz, Eberhard; Mollnau, Hanke; von Sandersleben, Alexandra; Kleschyov, Andrei L; Mülsch, Alexander; Li, Huige; Förstermann, Ulrich; Münzel, Thomas

Oelze, Matthias; Daiber, Andreas; Brandes, Ralf P; Hortmann, Marcus; Wenzel, Philip; Hink, Ulrich; Schulz, Eberhard; Mollnau, Hanke; von Sandersleben, Alexandra; Kleschyov, Andrei L; Mülsch, Alexander; Li, Huige; Förstermann, Ulrich; Münzel, Thomas.

Affiliation

Oelze M; Johannes Gutenberg University Hospital, Division of Cardiology, Mainz, Germany.

Hypertension ; 48(4): 677-84, 2006 Oct.

Article in En | MEDLINE | ID: mdl-16940222

Subject(s)

Adrenergic beta-Antagonists/pharmacology; Angiotensin II/pharmacology; Benzopyrans/pharmacology; Endothelium, Vascular/drug effects; Endothelium, Vascular/physiopathology; Ethanolamines/pharmacology; NADPH Oxidases/metabolism; Superoxides/antagonists & inhibitors; Superoxides/metabolism; Acridines; Animals; Blood Vessels/metabolism; Cell Line; Cyclic GMP/metabolism; Dicarbethoxydihydrocollidine/analogs & derivatives; Fluorescence; Hemoglobins/metabolism; Humans; Luminescence; Luminescent Agents; Luminol/analogs & derivatives; Male; Myocardium/metabolism; Nebivolol; Nitric Oxide/blood; Nitric Oxide/metabolism; Nitric Oxide Synthase Type III/metabolism; Nitrites/blood; Phosphoproteins/metabolism; Rats; Rats, Wistar; Signal Transduction/drug effects; rac1 GTP-Binding Protein/metabolism

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Benzopyrans / Angiotensin II / Endothelium, Vascular / Superoxides / Adrenergic beta-Antagonists / NADPH Oxidases / Ethanolamines Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Hypertension Year: 2006 Type: Article Affiliation country: Germany

Search on Google

XML

PubMed Links