Endogenous insulin signaling protects cultured neurons from oxygen-glucose deprivation-induced cell death.

Mielke, J G; Taghibiglou, C; Wang, Y T

Mielke, J G; Taghibiglou, C; Wang, Y T.

Affiliation

Mielke JG; Neurobiology Program, Institute for Biological Sciences, National Research Council of Canada, Building M-54, Ottawa, Ontario, Canada K1A 0R6. john.mielke@nrc.ca

Neuroscience ; 143(1): 165-73, 2006 Nov 17.

Article in En | MEDLINE | ID: mdl-16978790

Subject(s)

Glucose/deficiency; Hypoxia/physiopathology; Insulin/physiology; Neurons/physiology; Signal Transduction/physiology; Animals; Blotting, Western/methods; Cell Death/physiology; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors/pharmacology; Enzyme-Linked Immunosorbent Assay/methods; Hypoglycemic Agents/pharmacology; Immunohistochemistry/methods; Immunoprecipitation/methods; Metformin/pharmacology; Neurons/cytology; Neurons/drug effects; Protein Binding/physiology; Rats; Rats, Wistar; Receptor, Insulin/metabolism; Signal Transduction/drug effects; Time Factors; Tyrphostins/pharmacology

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Glucose / Insulin / Hypoxia / Neurons Type of study: Prognostic_studies Limits: Animals Language: En Journal: Neuroscience Year: 2006 Type: Article

Search on Google

XML

PubMed Links