Donepezil primarily attenuates scopolamine-induced deficits in psychomotor function, with moderate effects on simple conditioning and attention, and small effects on working memory and spatial mapping.

Lindner, Mark D; Hogan, John B; Hodges, Donald B; Orie, Anitra F; Chen, Ping; Corsa, Jason A; Leet, John E; Gillman, Kevin W; Rose, Gregory M; Jones, Kelli M; Gribkoff, Valentin K

Lindner, Mark D; Hogan, John B; Hodges, Donald B; Orie, Anitra F; Chen, Ping; Corsa, Jason A; Leet, John E; Gillman, Kevin W; Rose, Gregory M; Jones, Kelli M; Gribkoff, Valentin K.

Affiliation

Lindner MD; Department 401, Neuroscience Drug Discovery, Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492, USA. Mark.Lindner@BMS.com

Psychopharmacology (Berl) ; 188(4): 629-40, 2006 Nov.

Article in En | MEDLINE | ID: mdl-17004085

Subject(s)

Cholinesterase Inhibitors/pharmacology; Cognition Disorders/drug therapy; Indans/pharmacology; Piperidines/pharmacology; Psychomotor Disorders/drug therapy; Animals; Attention/drug effects; Cognition Disorders/chemically induced; Conditioning, Psychological/drug effects; Donepezil; Male; Maze Learning/drug effects; Memory/drug effects; Muscarinic Antagonists; Psychomotor Disorders/chemically induced; Rats; Rats, Sprague-Dawley; Scopolamine

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Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Psychomotor Disorders / Cholinesterase Inhibitors / Cognition Disorders / Indans Type of study: Prognostic_studies Limits: Animals Language: En Journal: Psychopharmacology (Berl) Year: 2006 Type: Article Affiliation country: United States

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