Prognostic and biological implications of genetic abnormalities in multiple myeloma undergoing autologous stem cell transplantation: t(4;14) is the most relevant adverse prognostic factor, whereas RB deletion as a unique abnormality is not associated with adverse prognosis.

Gutiérrez, N C; Castellanos, M V; Martín, M L; Mateos, M V; Hernández, J M; Fernández, M; Carrera, D; Rosiñol, L; Ribera, J M; Ojanguren, J M; Palomera, L; Gardella, S; Escoda, L; Hernández-Boluda, J C; Bello, J L; de la Rubia, J; Lahuerta, J J; San Miguel, J F

Gutiérrez, N C; Castellanos, M V; Martín, M L; Mateos, M V; Hernández, J M; Fernández, M; Carrera, D; Rosiñol, L; Ribera, J M; Ojanguren, J M; Palomera, L; Gardella, S; Escoda, L; Hernández-Boluda, J C; Bello, J L; de la Rubia, J; Lahuerta, J J; San Miguel, J F.

Affiliation

Gutiérrez NC; Servicios de Hematología: Hospital Universitario de Salamanca and Centro de Investigación del Cáncer (CIC), Universidad de Salamanca-CSIC, Spain.

Leukemia ; 21(1): 143-50, 2007 Jan.

Article in En | MEDLINE | ID: mdl-17024116

Subject(s)

Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 4; Gene Deletion; Genes, Retinoblastoma; Multiple Myeloma; Stem Cell Transplantation; Translocation, Genetic; Adult; Aged; Female; Humans; Male; Middle Aged; Multiple Myeloma/genetics; Multiple Myeloma/therapy; Multivariate Analysis; Prognosis; Survival Analysis; Transplantation, Autologous

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Collection: 01-internacional Database: MEDLINE Main subject: Translocation, Genetic / Chromosomes, Human, Pair 4 / Chromosomes, Human, Pair 14 / Genes, Retinoblastoma / Gene Deletion / Stem Cell Transplantation / Multiple Myeloma Type of study: Clinical_trials / Guideline / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2007 Type: Article Affiliation country: Spain

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