Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.

Lagouge, Marie; Argmann, Carmen; Gerhart-Hines, Zachary; Meziane, Hamid; Lerin, Carles; Daussin, Frederic; Messadeq, Nadia; Milne, Jill; Lambert, Philip; Elliott, Peter; Geny, Bernard; Laakso, Markku; Puigserver, Pere; Auwerx, Johan

Lagouge, Marie; Argmann, Carmen; Gerhart-Hines, Zachary; Meziane, Hamid; Lerin, Carles; Daussin, Frederic; Messadeq, Nadia; Milne, Jill; Lambert, Philip; Elliott, Peter; Geny, Bernard; Laakso, Markku; Puigserver, Pere; Auwerx, Johan.

Affiliation

Lagouge M; Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS / INSERM / ULP, 67404 Illkirch, France.

Cell ; 127(6): 1109-22, 2006 Dec 15.

Article in En | MEDLINE | ID: mdl-17112576

Subject(s)

Metabolic Diseases/prevention & control; Mitochondria, Muscle/physiology; Sirtuins/genetics; Sirtuins/metabolism; Stilbenes/pharmacology; Trans-Activators/metabolism; Acetylation; Adult; Animals; Dietary Fats/administration & dosage; Energy Metabolism/drug effects; Gene Expression Regulation/drug effects; Humans; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Motor Activity/drug effects; Muscle Fibers, Skeletal/physiology; Obesity/prevention & control; Oxidative Phosphorylation; Oxygen Consumption/drug effects; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Polymorphism, Single Nucleotide; Resveratrol; Sirtuin 1; Specific Pathogen-Free Organisms; Transcription Factors

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Stilbenes / Trans-Activators / Sirtuins / Metabolic Diseases / Mitochondria, Muscle Limits: Adult / Animals / Humans / Male Language: En Journal: Cell Year: 2006 Type: Article Affiliation country: France

Search on Google

XML

PubMed Links